Andreas Vierling

Master Student

Determination of cancer pathogenicity at single cell scale

Betreuer: Dr. Aldo Leal-Egana, Prof. Dr.-Ing. habil. Aldo R. Boccaccini

Metastatic cancer cells can be detected by their several characteristic cues, such as migration speed, morphology and exertion of traction forces [1]. During the present Master thesis project, the research wil focus on studying physiological and biophysical differences found between cells cultured on 2D flat surfaces (traditional strategy) and those previously cultured in entrapment (immobilizing cells within 3D tumor like microcapsules).

[1] Leal-Egaña A, Letort G, Martiel JL, Christ A, Vignaud T, Roelants C, Filhol O, Théry M. The size-speed-force relationship governs migratory cell response to tumorigenic factors. Mol Biol Cell. 2017; 28:1612-1621.