Dr. Miguel Fuentes Chandia

Gastwissenschaftler

Advanced matrices for cancer research

Mitarbeiter: Dr. Aldo Leal-Egaña, Prof. Aldo R. Boccaccini

This research project is focused on designing and developing a miniaturized scaffold resembling mechanical and topographic properties of Cancer niches. In order to reach this goal, hydrogels with defined cues will be used. This approach allows us generating an in vitro platform for studying tumor heterogeneity. Tumor heterogeneity can be described as the existence of multiple sub-populations within metastatic tumors, exhibiting difference in migration, proliferation and pharmacologic sensitivity. Thus, the presence of this pathogenic characteristic will be studied with biomaterials in vitro, mimicking the in vivo milieu.

[1 Leal-Egaña A, Letort G, Martiel JL, Christ A, Vignaud T, Roelants C, Filhol O, Théry M. The size-speed-force relationship governs migratory cell response to tumorigenic factors. Mol Biol Cell. 2017; 28:1612-1621.

[2] Ivanovska J, Zehnder T, Lennert P, Sarker B, Boccaccini AR, Hartmann A, Schneider-Stock R, Detsch R. Biofabrication of 3D Alginate-Based Hydrogel for Cancer Research: Comparison of Cell Spreading, Viability, and Adhesion Characteristics of Colorectal HCT116 Tumor Cells. Tissue Eng Part C Methods. 2016; 22:708-15.

[3] Weinstein-Oppenheimer CR, Aceituno AR, Brown DI, Acevedo C, Ceriani R, Fuentes MA, Albornoz F, Henríquez-Roldán CF, Morales P, Maclean C, Tapia SM, Young ME. The effect of an autologous cellular gel-matrix integrated implant system on wound healing. J Transl Med. 2010; 8:59.