Lisa Schöbel, M. Sc.
Development and Characterisation of Electrically Conductive Hydrogels for Tissue Engineering Applications
Supervisor: Prof. Dr.-Ing. habil. Aldo R. Boccaccini
It has been shown that cell growth and differentiation can be controlled by the use of conductive materials and, if necessary, electrical stimulation . Biomaterials that provide electrical conductivity are especially of interest for applications in bone, cartilage or neural tissue engineering. The potential of ADA-GEL in tissue engineering and biofabrication was proven extensively in the past few years [2,3]. This project (B01), which belongs to the DFG Collaborative Research Center 1270 – Electrically Active Implants (ELAINE) led in its second funding period by the University of Rostock, aims to develop functional biomaterials based on an oxidized-alginate (ADA) and gelatin (GEL) hydrogel systems with tailorable conductivity. The first attempts to render ADA-GEL electrically conductive by a combination of in situ and interfacial polymerization with Polypyrrole (PPy) have shown promising results . Therefore, this project strives towards developing further knowledge of electrically active hydrogel materials that could act as ECM-like matrices. Key collaborator in this project is Prof. Dr.-Ing. Hermann Seitz of the Institute of Fluid Technology and Microfluidics at the University of Rostock.
 Stewart, E. et al. “Electrical stimulation using conductive polymer polypyrrole promotes differentiation of human neural stem cells: a biocompatible platform for translational neural tissue engineering.” Tissue Engineering Part C: Methods 21.4 (2015): 385-393.
 Reakasame, S. and Boccaccini, A. R. (2018). Oxidized alginate-based hydrogels for tissue engineering applications: a review. Biomacromolecules, 19(1), 3-21.
 Sarker, B. et al. (2014). Evaluation of fibroblasts adhesion and proliferation on alginate-gelatin crosslinked hydrogel. PloS one, 9(9), e107952.
 Distler, T. et al. (2021). Electrically Conductive and 3D‐Printable Oxidized Alginate‐Gelatin Polypyrrole: PSS Hydrogels for Tissue Engineering. Advanced Healthcare Materials, 10(9), 2001876.