Achim Dürschner

Bachelor student

Preparation and properties of mesoporous bioactive glass nanoparticles loaded with Rose Bengal

 

Supervisor: Meng Li, Prof. Aldo R. Boccaccini

Mesoporous bioactive glass nanoparticles (MBGN) are characterized by high specific surface area, ordered pore structure, and controllable pore size distribution [1]. MNGN can be used as delivery carriers for drugs or active factors, and thus have important applications in the field of biomaterials.

Rose Bengal (RB) is an efficient photosensitizer with antibacterial, antifungal, anticancer activity [2]. Therefore, we can use the excellent mesoporous properties of MBGN with the high efficiency of RB as an allergenic agent to make MBGN loaded with RB to obtain materials with advanced functionalities.

This thesis will involve the preparation of MBGN as a starting point to investigate the loading and release properties of Rose Bengal. MBGN and Cu@MBGN will be prepared by sol-gel method, and the in vitro bioactivity of the two mesoporous bioactive glasses will be examined by using simulated body fluid (SBF). The loading and release behaviors of MBGN and Cu@MBGN on Rose Bengal will be examined.

 

[1] Zheng K, Kang J, Rutkowski B , et al. Toward Highly Dispersed Mesoporous Bioactive Glass Nanoparticles With High Cu Concentration Using Cu/Ascorbic Acid Complex as Precursor. Frontiers in Chemistry, 2019,7: 497.

[2]Gurianov Y, Meistelman M, Albo Y, et al. Antibacterial Activity of Rose Bengal Entrapped in Organically Modified Silica Matrices. International Journal of Molecular Sciences, 2022, 23(7): 3716.