Tailoring the dissolution kinetics of mesoporous ion-doped bioactive glasses under different conditions for drug delivery applications
Supervisors: Dr. Dagmar Galusková (Trenčín), Prof. Dr.-Ing. habil. Aldo R. Boccaccini
Akrity Anand is a PhD student in the framework of the EU-funded HORIZON 2020 project FunGlass (Centre for Functional and Surface Functionalized Glass) based at Alexander Dubček University of Trenčín. Ms. Anand started her training period in September 2021 at the Institute of Biomaterials (FAU), which is an international advanced project partner of FunGlass. Within this project Cu and co-doped mesoporous bioactive glass (MBG) will be prepared to offer multifunctional effects on bone formation such as osteogenesis, angiogenesis as well as antibacterial activities [1,2]. Dissolution behaviour of doped and co-doped MBG ions will be studied in simulated body fluids and based on the static and dynamic experiments the mechanism of dissolution of ion-doped and co-doped bioactive glasses will be proposed. Bioactivity and biocompatibility tests, antibacterial studies and drug delivery assays will provide complex information for the selection of co-doped MBG releasing therapeutic ions in a controlled manner into a physiological environment to achieve osteogenic and angiogenic functionalities and at the same time drug delivery capability.
 Hoppe, Alexander, Nusret S. Güldal, and Aldo R. Boccaccini. “A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics.” Biomaterials 32, no. 11 (2011): 2757-2774.
 Lalzawmliana, V., Akrity Anand, Mangal Roy, Biswanath Kundu, and Samit Kumar Nandi. “Mesoporous bioactive glasses for bone healing and biomolecules delivery.” Materials Science and Engineering: C 106 (2020): 110180.