Biocompatible and mechanical robust 3D printed ADA-GEL scaffolds loaded with phytochemicals and naturally derived substances for skin tissue engineering applications
Supervisors: Memoona Akhtar, Prof. Aldo R. Boccaccini
ADA-GEL is the combination of alginate di-aldehyde and gelatin, which gains high biocompatibility, adjustable biodegradability and low production cost . Natural products including plant-derived extracts (phytochemicals) and naturally derived substances are important alternative medicines, which are safe and effective . The aim of this study is to design a biocompatible and robust ADA-GEL scaffold for skin tissue engineering which is loaded with natural compounds, in relation with previous recent research in our Institute  Related properties will be tested, including biocompatibility, mechanical properties, drug-release kinetic, etc.
 Reakasame S, Boccaccini AR. Oxidized Alginate-Based Hydrogels for Tissue Engineering Applications: A Review. Biomacromolecules 2018; 19(1):3–21.
 Sivamani, Raja K., et al. Phytochemicals and Naturally Derived Substances for Wound Healing. Advances in Wound Care, 2012, 1: 213–17.
 Monavari, M., et al., A 3D-Printed Wound-Healing Material Composed of Alginate Dialdehyde–Gelatin Incorporating Astaxanthin and Borate Bioactive Glass Microparticles, ACS Appl. Mater. Interfaces 2023, in press.