Biofabrication using Methylcellulose Based Bioink
Betreuer: Supachai Reakasame, Prof. Aldo R. Boccaccini
Biofabrication is a widely used tissue engineering technique which allows pre-defined deposition of cell containing hydrogels (bioinks). Combination of materials like oxidized alginate (ADA) and gelatin could be used for bioinks due to suitable properties for cell growth . However, further developments of bioinks is required to print complex 3D structures. In this work, the use of methylcellulose to improve the printability of ADA-gelatin bioink will be evaluated to achieve robust 3D robust constructs for biofabrication  The scope of the project includes hydrogel characterization as well as cell viability studies of the created 3D structures.
 T. Zehnder, B. Sarker, A. R. Boccaccini and R. Detsch, Evaluation of an alginate–gelatine crosslinked hydrogel for bioplotting, Biofabrication 7 (2015) 025001.
 K. Schütz et al., Three‐dimensional plotting of a cell‐laden alginate/methylcellulose blend: towards biofabrication of tissue engineering constructs with clinically relevant dimensions, J Tissue Eng Regen Med. 11 (2017) 1574-1587.