3D biofabrication of hydrogels based on oxidized hyaluronic acid
Supervisors: Sonja Kuth, Prof. Aldo R. Boccaccini
Hyaluronic acid (HA) is a linear polysaccharide present in the human extracellular matrix (ECM). HA has biocompatibility and water holding capacity, therefore HA-based hydrogels have been widely used in tissue engineering . However, the applications of HA hydrogels are limited by their poor mechanical properties and higher rate of hydrolytic degradation. Oxidation of HA with Sodium metaperiodate (NaIO4) can form oxidized HA (OHA). The multiple aldehyde groups contained in OHA can easily react with materials containing amino functional groups to form Schiff base linkage, thus further forming OHA-based hydrogel scaffolds [2, 3].
Extrusion 3D printing it is a manufacturing technology for constructing biological scaffolds with complex functions under computer-aided design . In the research we aim to use 3D printing to prepare OHA/gelatin-based hydrogel scaffolds for tissue engineering.
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