Influence of different oxidation degrees on the degradation behavior and mechanical properties of hyaluronic acid based hydrogels
Supervisors: Sonja Kuth, Prof. Aldo R. Boccaccini
Soft tissue engineering requires the development of biomaterials which mimic the complex extracellular matrix. Hydrogels are three-dimensional networks consisting of crosslinked hydrophilic polymers, that have a high capacity to absorb aqueous solvents and biological fluids within their structure . For their later application they require specific mechanical and physical properties. The degradation rate, for example, influences the performance of the scaffold. It can be inter alia influenced by varying the degree of oxidation, changing the crosslinking density or adding different components . In order to achieve appropriate properties of the hydrogels, the aim of this project is to evaluate the influence of the degree of oxidation and crosslinking on oxidized hyaluronic acid and gelatin hydrogels.
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