Investigation of biphasic scaffolds for osteochondral defect repair
Supervisor: Lisa Schoebel, Prof. Aldo R. Boccaccini
The healing response of bone occurs after a fracture. However, if the bone loss exceeds a critical threshold, it is no longer able to perform complete self-repair . In this case, external support by scaffolds is required which can efficiently be manufactured by additive manufacturing . In this project, the aim is to fabricate biphasic scaffolds for osteochondral defect repair using poly(lactic acid)-bioactive glass (PLA-BG) composites  as the bone part and alginate di-aldehyde-gelatin (ADA-GEL) hydrogels as the cartilage part. The final scaffolds will be investigated regarding their 3D-printability, chemical and mechanical properties as well as bioactive properties and cell-material interactions
 G. Kumar and B. Narayan, “The biology of fracture healing in long bones,” Class. Pap. Orthop., pp. 531–533, 2014.
 S. Bose, S. Vahabzadeh, and A. Bandyopadhyay, “Bone tissue engineering using 3D printing,” Mater. Today, vol. 16, no. 12, pp. 496–504, 2013.
 T. Distler, et al., “Polymer-Bioactive Glass Composite Filaments for 3D Scaffold Manufacturing by Fused Deposition Modeling: Fabrication and Characterization”, Front. Bioeng. Biotechnol. 8:552, 2020.