Louisa Susanne Werner

 Bachelor student

Formulation and characterization of a chitosan/gelatin-based coating with mesoporous bioactive glass nanoparticles loaded with plant derived antibacterial compounds

Supervisors: Daniela Sofia Del Salto, Prof. Aldo R. Boccaccini

One of the main issues of implant failing is due to bacterial adhesion and biofilm formation on the implant. To reduce the risk of complications, antibacterial and bioactive coatings are developed to ensure a better healing process [1].  In this context, hybrid coating systems combining mesoporous bioactive glass nanoparticles (MBGNs) with biopolymers are gaining increased attention. By integrating the drug release capability and bioactive properties of MBGNs, loaded with phytotherapeutic agents with antimicrobial and mucoadhesive characteristics of natural polymers, multifunctional coatings with improved biocompatibility can be achieved [2-4]. The thesis focuses on the development and characterization of a new coating, consisting of a chitosan/gelatin matrix, incorporating MBGNs, loaded with plant derived antibacterial compunds. The aim of this project is to develop a multifunctional coating, studying its physiochemical properties along with the bioactivity and controlled drug delivery of the phytotherapeutic agent, in order to enhance the antibacterial and bioactive properties.

[1] Campoccia D. et al.: The significance of infection related to orthopedic devices and issues of antibiotic resistance. Biomaterials, 27 (11), 2331–2339 (2006)

[2] Lesmana R. et al.: The Suitability of Propolis as a Bioactive Component of Biomaterials. Frontiers in Pharmacology, 13 (2022)

[3] Braier D. S.: Bioactive Glasses – Structure and Properties. Angewandte Chemie International Edition, 54, 4160-4181 (2015)

[4] Rinaudo M.: Chitin and Chitosan: Properties and Applications. Prog. Polym. Sci. 31(7), 603-632 (2006)