Visiting student (Mondragon University, Spain)
Coating of Ti-6Al-4V scaffolds with bioactive hydrogels for bone tissue engineering
Supervisors: Lisa Schöbel, Prof. Aldo R. Boccaccini
Several studies show that three-dimensional Ti-6Al-4V scaffolds support the regeneration of bone . However, titanium alloys do not always result in the expected osteointegration. Considering that the biological reaction is mainly dictated by the material’s surface, a bioactive hydrogel coating will be investigated in this project to tailor the hard-to-soft transition. This coating will be based on an alginate based hydrogel due to its biocompatibility, capacity to retain water and possibility to mimic the natural extracellular matrix (ECM) . The coatings will be investigated regarding their chemical and mechanical properties as well as their degradation behaviour.
 F. Deng, L. Liu, Z. Li, and J. Liu, “3D printed Ti6Al4V bone scaffolds with different pore structure effects on bone ingrowth,” Journal of Biological Engineering, vol. 15, no. 1, 2021, doi: 10.1186/s13036-021-00255-8.
 S. Reakasame and A. R. Boccaccini, “Oxidized Alginate-Based Hydrogels for Tissue Engineering Applications : A Review,” vol. 19, no. Biomacromolecules, pp. 3–21, 2018, doi: 10.1021/acs.biomac.7b01331.