Paula M. Riosalido de Lucas

Paula M. Riosalido de Lucas

Visiting PhD student (Institute of Bioengineering, University Miguel Hernández, Elche, Spain)

In Vitro Testing of Ion-Doped Multilayer Scaffolds

Supervisor in Erlangen: Prof. Aldo R. Boccaccini

The global demographic ageing of the population has led to an increase in the prevalence of bone defects, which has highlighted the need to effectively address these conditions through research and the development of innovative therapeutic strategies [1,2]. This research project proposes the creation of multilayer scaffolds based on the SiO2-CaO-P2O5 system. This approach enables the fabrication of biomimetic structures by integrating diverse biomaterials and their properties into a unified structure. The scaffolds under study comprise a core that provides mechanical strength, accompanied by a double bioactive coating that modulates the morphological and bioactive behaviour of the scaffolds based on its composition. The resulting scaffolds will be evaluated from a biological perspective, including assessment of their biocompatibility, osteoinductive and angiogenic properties.

  1. Orciani, M., Fini, M., di Primio, R., & Mattioli-Belmonte, M. (2017). Biofabrication and bone tissue regeneration: Cell source, approaches, and challenges. In Frontiers in Bioengineering and Biotechnology (Vol. 5, Issue MAR).
  2. Dec, P., Modrzejewski, A., & Pawlik, A. (2023). Existing and Novel Biomaterials for Bone Tissue Engineering. In International Journal of Molecular Sciences (Vol. 24, Issue 1).