Development and Characterization of Polyaniline (PANI) Containing Fiber Mats for a Potential Application in Cardiac Tissue Engineering
Supervisors: M.Sc. Lena Vogt, Prof. Dr.-Ing. habil. Aldo R. Boccaccini
Cardiovascular diseases (CVD) are one of the most prevalent health issues in the Western world. In particular, myocardial infarctions cause a high mortality rate associated with CVD. Myocardial infarctions often result in the loss of heart muscle cells (cardiomyocytes) and a subsequent formation of scar tissue, as myocardial tissue does not have good regenerative properties . To prevent heart failure, researchers aim to mimic the properties of natural myocardium and provide an approach to repair the diseased myocardium by using tissue-engineered scaffolds . The aim of this bachelor thesis is the development and characterization of electrospun fiber mats consisting of a polyester blend with incorporated PANi. The fiber mats will be analyzed regarding their morphological, physico-chemical and degradation properties.
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 Jiajia Xue, et al., Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications, Chem. Rev. 2019, 119, 5298−5415.