Sofía Del Salto

Biological And Mechanical Properties Of Propolis-Containing Antibacterial Coatings Based On A Chi-tosan/Gelatin Matrix Incorporated With Mesoporous Bioactive Glass Or Metal – Organic Framework Nano-particles: A Comparative Investigation

Supervisor: Prof. Dr.-Ing. habil. Dr. h. c. mult. Aldo R. Boccaccini

Infection is one of the main causes of implant failure leading to serious complications which can necessitate implant replacement and further problems linked to the recovery time of the patient [1]. Researchers worldwide are investigating the use of biomaterial- based drug delivery systems as part of implant coatings, in order to deliver locally and in a sustained manner different types of therapeutic agents, including phytotherapeutic agents, to prevent or cure infection and inflammation [2]. Therefore, this investigation will be focused on the developing of advanced coatings for orthopedic implants with the goal to enhance implant biocompatibility and to impart antibacterial effects. The coatings will be based on a natural polymer matrix incorporating diferent types of nanoparticles, for example mesoporous Bioactive Glass Nanoparticles (MBGNs) [3] loaded with plant derived extracts as phytotherapeutic agents.

[1] Sagnori, R. S., da Fonseca, V. J., Lima, L. H. F., Goulart, D. R., Asprino, L., de Moraes, M., & Sverzut, A. T. (2024). Early dental implant failure associated with postoperative infection: A retrospective 21-year study. Oral Surgery, 17(3), 214–220. https://doi.org/10.1111/ors.12875

[2] Ashtiani, R. E., Hadi, A., Nouri, F., Rahimi, S., Badkoobeh, A., Abbasi, K., & Alam, M. (2022). The role of current herbal extracts in bone regeneration through dental implants: In vitro/in vivo/clinical studies. Archives of Medical Science : AMS, 19(6), 1653–1661. https://doi.org/10.5114/aoms/153510

[3] Akhtar, M. A., et al. (2021).  Electrophoretic deposition of ferulic acid loaded bioactive glass/chitosan as antibacterial and bioactive composite coatings. Surface and Coatings Technology 405, 126657. https://doi.org/10.1016/j.surfcoat.2020.126657