Thomas Kreller, M. Sc.
Electrical Stimulation of bone cells
Betreuer: Dr. R. Detsch, Prof. Dr.-Ing. habil. Aldo R. Boccaccini
Electrical stimulation (ES) has long been used to successfully treat non-healing bone fractures and has recently been shown to stimulate bone cells to migrate, proliferate, align and differentiate . The objective of the DFG project “Electrical Stimulation of bone cells” is the consolidation of both osteoblasts and osteoclasts in one ES set-up to provide similar stimulation conditions. This project involves collaboration of our Institute (PI: Dr. R. Detsch) with Dr. Anika Jonitz-Heincke, Orthopaedic Hospital and Polyclinic, University Medicine Rostock. The influence of ES on bone remodelling (cell proliferation, differentiation and activation of mesenchymal and hematopoietic stem cells) will be systematically investigated in-vitro. Based on the relevance of osteoclasts in bone metabolism and healing , this project focuses initially on the electrical stimulation of monocytes, pre-osteoclasts and osteoclast-like cells on modified metallic substrates. To achieve this goal electroconductive materials will be functionalized to mimic natural bone surfaces . Various coating methods will be adapted and evaluated.
 L. Leppik et al., “Combining electrical stimulation and tissue engineering to treat large bone defects in a rat model”, Sci. Rep., vol. 8, no. 1, pp. 1–14, 2018.
 R. Detsch and A. R. Boccaccini, “The role of osteoclasts in bone tissue engineering”, J. Tissue Eng. Regen. Med., vol. 9, pp. 1133-1149, 2015.
 J. Hum and A. R. Boccaccini, “Collagen as coating material for 45S5 bioactive glass-based scaffolds for bone tissue engineering”, Int. J. Mol. Sci., vol. 19, no. 6, 2018.