Tim Fuggerer

Bachelor student

Fabrication and Characterization of Electrospun Polycaprolactone/Gelatin Nanofiber Mats Incorporating Phytotherapeutics as Coating for 45S5 Bioactive Glass Scaffolds

 

Supervisor: Irem Unalam, Prof. Dr.-Ing. habil. Aldo R. Boccaccini

45S5 bioactive glass derived scaffolds are a promising material for bone tissue engineering due to their osteoconductive, osteogenic and angiogenic properties [1]. Phytotherapeutic (PT) agents can exhibit anti-inflammatory, antibacterial and antimicrobial functionalities. Therefore, the incorporation of PT agents as coatings of 45S5 bioactive glass scaffolds is an alternative approach to improve antibacterial properties for bone tissue engineering applications. In this Bachelor thesis, the aim is to fabricate and characterize PT incorporated 45S5 bioactive glass coated with electrospun PCL/gelatin nanofiber mats. The 45S5 bioactive glass scaffolds will be produced by replica foam technique [2]. The obtained scaffolds will be investigated regarding their morphological, chemical, mechanical, bioactivity and antibacterial properties.

 

[1] Reiter, T. et al., Bioactive glass based scaffold coated with gelatin for the sustained release of icariin. Bioactive Materials 4 (2019) 1-7.

[4] Chen QZ, et al., 45S5 Bioglass®-derived glass–ceramic scaffolds for bone tissue engineering. Biomaterials 27 (2006) 2414-2425.