Florian Ruther
Florian Ruther
Former PhD student
Development of a cardiac patch based on a bilayer, conductive, biomimetic, polymeric scaffold
Supervisor: Prof. Dr.-Ing. habil. Aldo R. Boccaccini
This project, funded by DFG, aims to fabricate and characterize a novel type of bilayer, conductive, biomimetic polymer scaffold suitable for heart tissue engineering applications in the form of a cardiac patch [1]. The project will be focused on the integration of a porous scaffold as a mechanical carrier and an electrospun scaffold exhibiting electrical conductivity. In particular, considering the known effects of myocardial cells on electrical stimulation, electrical conductive mats will be fabricated via electrospinning. Furthermore, to match mechanical conditions of heart tissue and to enhance vascularisation, a porous membrane will be used, which will be fabricated by standard methods. The novel scaffolds will be then analyzed regarding their mechanical, conductive and biomimetic properties. The project is being carried out in collaboration with Prof. Felix Engel (Professorship for Experimental Renal and Cardiovascular Research, University Hospital Erlangen).
[1] QZ Chen, SE Harding, NN Ali, AR Lyon, AR Boccaccini, Biomaterials in cardiac tissue engineering: ten years of research survey, Materials Science and Engineering: R: Reports 59 (1) (2008), 1-37.
2022
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DEVELOPMENT OF APPROACHES FOR A TWO-LAYER PATCH COMBINING ELECTROSPINNING AND 3D PRINTING WITH IMPROVED ELECTRICAL STIMULUS TRANSMISSION AND SELF-REGULATING VISCOELASTIC PROPERTIES FOR APPLICATION IN CARDIAC TISSUE ENGINEERING
In: TISSUE ENGINEERING PART A, NEW ROCHELLE: 2022 - , , :
3D Printing of Mechanically Resistant Poly (Glycerol Sebacate) (PGS)-Zein Scaffolds for Potential Cardiac Tissue Engineering Applications
In: Advanced Engineering Materials (2022)
ISSN: 1438-1656
DOI: 10.1002/adem.202101768 - , , , , , , , :
Environmentally friendly fabrication of electrospun nanofibers made of polycaprolactone, chitosan and k-carrageenan (PCL/CS/k-C)
In: Biomedical Materials 17 (2022)
ISSN: 1748-6041
DOI: 10.1088/1748-605X/ac6eaa
2021
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Poly(Glycerol Sebacate) in Biomedical Applications—A Review of the Recent Literature
In: Advanced Healthcare Materials (2021)
ISSN: 2192-2640
DOI: 10.1002/adhm.202002026
2019
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Development of 3D Biofabricated Cell Laden Hydrogel Vessels and a Low-Cost Desktop Printed Perfusion Chamber for In Vitro Vessel Maturation
In: Macromolecular Bioscience (2019), Article No.: 1900245
ISSN: 1616-5187
DOI: 10.1002/mabi.201900245 - , , , , , :
Nanofibrous Composite with Tailorable Electrical and Mechanical Properties for Cardiac Tissue Engineering
In: Advanced Functional Materials (2019), Article No.: 1908612
ISSN: 1616-301X
DOI: 10.1002/adfm.201908612 - , , , :
Biofabrication of vessel-like structures with alginate di-aldehyde—gelatin (ADA-GEL) bioink
In: Journal of Materials Science: Materials in Medicine 30 (2019), Article No.: 8
ISSN: 0957-4530
DOI: 10.1007/s10856-018-6205-7 - , , , :
Improvement of the Layer Adhesion of Composite Cardiac Patches
In: Advanced Engineering Materials (2019), Article No.: 1900986
ISSN: 1438-1656
DOI: 10.1002/adem.201900986
2018
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3D Microcontact Printing for Combined Chemical and Topographical Patterning on Porous Cell Culture Membrane.
In: ACS Applied Materials and Interfaces 10 (2018), p. 22857-22865
ISSN: 1944-8244
DOI: 10.1021/acsami.8b06585 - , , , :
Biofabrication of vessel-like structures with alginate di-aldehyde-gelatin (ADA-GEL) bioink.
In: Journal of Materials Science: Materials in Medicine 30 (2018), p. 8
ISSN: 0957-4530
DOI: 10.1007/s10856-018-6205-7
2016
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Development of a biofabrication process for the manufacture of vessel like structures
Annual Conference of the German Society for Biomaterials 2016 (Aachen, 29th September 2016 - 1st October 2016)
In: BioNanoMaterials (ed.): Band 17, Berlin/Boston: 2016
DOI: 10.1515/bnm-2016-1001.