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Our paper on Cu-bioactive glass containing injectable gels in collaboration with Huazhong University of Science and Technology researchers published in Acta Biomaterialia

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The paper “Thermally triggered injectable chitosan/silk fibroin/bioactive glass nanoparticle hydrogels for in-situ bone formation in rat calvarial bone defects”, presenting results of our collaboration with colleagues at National Engineering Research Center for Nanomedicine, and Department of Orthopaedics, Huazhong University of Science and Technology,Wuhan, China (leading author: Prof. Ying Wan), has been published in Acta Biomaterialia, one of the top journals in the field of biomaterials [1]. The study is based on the project carried out by Ms Jingjing Wu during her research stay in our Institute and presents the development, characterization and applications on an innovative composite injectable hydrogel based on incorporating copper-doped bioactive glass nanoparticles, synthesised in our Institute in Erlangen, in a chitosan based hydrogel matrix exhibiting thermally triggered in-situ gelation. The composite was shown to achieve angiogenic and osteogenic properties and was able to fully repair critical-size rat calvarial bone defects without using growth factors. [1] Wu, J., Zheng, K., Huang, X., Liu, J., Liu, H., Boccaccini, A. R., Wan, Y., Guo, X., Shao, Z., Thermally triggered injectable chitosan/silk fibroin/bioactive glass nanoparticle hydrogels for in-situ bone formation in rat calvarial bone defects, Acta Biomater. 91 (2019) 60-71.