Our new paper on bioactive glasses in collaboration with colleagues at University of Heidelberg published in Biomaterials Science
Our paper “Favorable angiogenic properties of the borosilicate bioactive glass 0106-B1 result in enhanced in vivo osteoid formation compared to 45S5 Bioglass” has been published in Biomaterials Science . (Co-authors: F. Westhauser, B. Widholz, Q. Nawaz, S. Tsitlakidis, S. Hagmann, A. Moghaddam, A. R. Boccaccini). In this comprehensive experimental study, we compared the in vitro and in vivo performances of two bioactive glasses, namely Hench’s 45S5 bioactive glass and a novel Boron containing formulation (0106-B1) in terms of angiogenic properties and in vivo osteoid formation ability. Osteogenic differentiation, viability and proliferation of human mesenchymal stromal cells (MSCs) were assessed /in vitro/. Furthermore, MSC-seeded scaffolds were implanted subcutaneously in immunodeficient mice. An important finding was that the superior angiogenic properties of 0106-B1-BG resulted in improved osteogenic properties /in vivo/, concluding that this novel 0106-B1 formulation is a promising bioactive glass for further investigation for bone tissue engineering. The in vitro and in vivo studies were led by the team of Dr. Fabian Westhauser at University of Heidelberg.
 F. Westhauser, et al. Favorable angiogenic properties of the borosilicate bioactive glass 0106-B1 result in enhanced in vivo osteoid formation compared to 45S5 Bioglass, Biomater. Sci. (2019) in press.