TRR225 Collaborative Research Centre new publication: biofabrication with oxidized alginate-gelatine based hydrogels

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Our publication (short communication) entitled “Cell-laden alginate dialdehyde–gelatin hydrogels formed in 3D printed sacrificial gel”has been published in J. Mater. Sci. Mater. Med. The research presented in this paper was carried out in the context of the doctoral thesis of Dr. Supachai Reakasame (Boo), the Master thesis of Ms Dalia Dranseikiene, and in collaboration with the research group of Prof. Dirk Schubert (Institute of Polymer Materials, FAU) with support of the Collaborative Research Centre TRR/SFB 225 “From the fundamentals of biofabrication towards functional tissue models”. In this work, ring shaped constructs of ADA–GEL hydrogel were fabricated by casting the hydrogel into sacrificial molds, which were previously 3D printed from methylcellulose 5% gelatin. The effect of different crosslinkers (Ba2+ and Ca2+) on the physicochemical properties of the hydrogel and on the behavior of encapsulated cells was investigated. The approach introduced in this paper could be further developed for cell-laden ADA–GEL bioink printing into complex 3D structures.

[1] D. Dranseikiene, et al., Cell-laden alginate dialdehyde–gelatin hydrogels formed in 3D printed sacrificial gel,J. Mater. Sci: Mater. Med. 31, (2020) 31.