Navigation

Our paper on bioactive glass-protein interactions published in Advanced Materials Interfaces

Our paper entitled “Effects of Medium pH and Preconditioning Treatment on Protein Adsorption on 45S5 Bioactive Glass Surfaces” has been published (Open Access) in Adv. Mater. Interf. [1]. This paper presents results of a successful collaboration with different research groups at the FAU Faculty of Engineering under the umbrella of of the Cluster of Excellence “Engineering of Advanced Materials” (EAM) (project EXC 315). Protein adsorption determines the biocompatibility of bioactive glasses (BGs) as it guides the subsequent cellular response. The influence of medium pH on protein adsorption taking place on flat bioactive glass surfaces (45S5 composition) was investigated. At lower pHs, BGs were found to adsorb a larger amount of proteins. It was also demonstrated that preconditioning BGs in simulated body fluid (SBF) attenuated the pH-dependent protein adsorption due to the formation of HA crystals in SBF (bioactivity of the BGs). Results of protein (albumin) adsorption for comparison of bioactive glasses with “bioinert” glasses, such as window glass and borosilicate glass, were also presented.

[1] S. Hoehn, et al., Effects of Medium pH and Preconditioning Treatment on Protein Adsorption on 45S5 Bioactive Glass Surfaces, Adv. Mater. Interf. (2020) in press.