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SFB 1270 “ELAINE”: Our new publication in ACS Biomater. Sci. Eng.

Our new paper entitled “Ionically and Enzymatically Dual Cross-Linked Oxidized Alginate Gelatin Hydrogels with Tunable Stiffness and Degradation Behavior for Tissue Engineering”, has just been published in ACS Biomater. Sci. Eng. This paper results from our research activities in the framework of the Collaborative Research Centre/SFB 1270 “Electrically Active Implants” (ELAINE) project B01, led by Thomas Distler (PhD student). In this study we show that it is possible to tune the stiffness and degradation behaviour of high gelatine content (> 60%) oxidized alginate (ADA)-gelatine (GEL) hydrogels by enzymatic crosslinking using microbial transglutaminase. The hydrogels are stable for up to 30 days in vitro and show cytocompatibility to NIH3T3, ATDC5, and HUVEC cells, allowing for long-term cell culture in tissue engineering applications.

Figure: Concept of microbial transglutaminase and Ca^2+ crosslinked high gelatin-content oxidized alginate gelatin (ADA-GEL) hydrogels (from ref. [1])

[1] T. Distler, K. McDonald, S. Heid, E. Karakaya, R. Detsch, A.R. Boccaccini, Ionically and Enzymatically Dual Cross-Linked Oxidized Alginate Gelatin Hydrogels with Tunable Stiffness and Degradation Behavior for Tissue Engineering, ACS Biomaterials Science & Engineering (2020). Copyright 2020 American Chemical Society.

 

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