3D printed alginate-di-aldehyde/gelatin dual crosslinked hydrogel for cartilage tissue engineering: new publication
Our new paper entitled “3D printing and characterization of human nasoseptal chondrocytes laden dual crosslinked oxidized alginate-gelatin hydrogels for cartilage repair approaches”  has been published in the journal Materials Science and Engineering C. This is the result of a collaboration led by Dr. Silke Schwarz and Prof. Gundula Schulze-Tanzil of the Department of Anatomy and Cell Biology, Paracelsus Medical University (PMU), Nuremberg and Salzburg, Nuremberg. In this work we investigated the applicability of an alginate-di-aldehyde (ADA) and gelatin (GEL), dual crosslinked hydrogel system for cartilage tissue engineering.We showed that neither the printing procedure nor the dual crosslinking had a harming effect on primary human nasoseptal chondrocytes. The formation of cartilage specific markers, including collagen type II, proteoglycans and SOX9, especially induced by the enzymatic crosslinking, was demonstrated by immunohistochemistry.
 S. Schwarz, S. Kuth, et al., 3D printing and characterization of human nasoseptal chondrocytes laden dual crosslinked oxidized alginate-gelatin hydrogels for cartilage repair approaches, Mater. Sci. Eng. C 116 (2020) 111189.